Translocations t(11;18)(q21;q21) and t(14;18)(q32;q21) are the main chromosomal abnormalities involving MLT/MALT1 in MALT lymphomas
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چکیده
منابع مشابه
Chromosomal translocations involving BCL6 in MALT lymphoma.
Chromosomal translocations involving BCL6 were detected in 7 out of 392 cases of MALT lymphoma by interphase fluorescence in situ hybridisation with a BCL6 break-apart probe. With the exception of BCL6 protein expression in 2 of the 7 cases, these BCL6 translocation-positive MALT lymphomas were histologically and immunophenotypically identical to classic cases.
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We analyzed the configuration of the CARMA1 gene, encoding a protein that closely interacts with BCL10 and MALT1, in a series of 120 extranodal marginal zone B-cell lymphomas of MALT-type and 35 diffuse large B-cell lymphomas. Our study suggests that CARMA1 is not targeted by chromosomal translocations in these lymphoma entities.
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ژورنال
عنوان ژورنال: Leukemia
سال: 2003
ISSN: 0887-6924,1476-5551
DOI: 10.1038/sj.leu.2403122